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Studies have shown that the TGF-1 signaling pathway is a major player in tissue fibrosis, including IPF (47), and this signaling pathway involves several critical phosphorylation events

Sun et al., 2016b

Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas

Intertumoral Heterogeneity One of the biggest challenges in treating GBM is intertumoral heterogeneity, which refers to the fact that different regions within a single GBM tumor can have different molecular and genetic profiles