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Toxins (Basel) 14:745

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

Esculetin (ESC) exhibits diverse anticancer mechanisms across different malignancies.(Top left)In hepatocellular carcinoma (HCC), ESC induces ferroptosis through multiple pathways: promoting ferritinophagy-mediated iron release from ferritin, suppressing antioxidant defenses (SLC7A11, GPX4, Nrf2), enhancing ACSL4-dependent lipid peroxidation, and increasing malondialdehyde (MDA) levels, ultimately leading to iron-dependent cell death.(Top right)In colorectal cancer (CRC), ESC disrupts copper homeostasis by upregulating the copper importer SLC31A1 (CTR1) and downregulating the copper exporter ATP7B, resulting in toxic copper accumulation and cuproptosis

Isolation and expression analysis of defense-related genes in sorghum - Colletotrichum sublineolum interaction

Creatine & Acetyl-L-Carnitine Energy puede promover la produccin de energa tanto para la mente como para el cuerpo

Dopamine gene therapy for Parkinsons disease in a nonhuman primate without associated dyskinesia