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In glaucoma, these responses are commonly triggered by chronically sustained high IOP and/or the subsequent death of RGCs, which produces a neurotoxic microenvironment that may impair the acceptance of donor cells by the host retina

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KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling

doi: 10.1021/acs.nanolett.6b02590 415 ZeinehM

Compared with sham rats, LOsG-treated rats had higher reactive oxygen species (ROS) levels in peripheral leukocytes and pancreatic tissue while TGF signalling was upregulated

This could be beneficial for managing inflammatory bowel diseases and other conditions related to inflammation