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Thereby, plasma drug concentrations and the therapeutic half-live may be reduced, necessitating dose adjustment (Cunningham 1982

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Review Article Volume 4 Issue 1 1 Department of Pharmacotoxicology and Pharmacokinentics, University of Yaound 2 Department of Microbiology, University of Yaound 3 Department of Phytochemistry and Pharmacognosy, University of Yaound Correspondence: Charles Fokunang, Department of Pharmacotoxicology and Pharmacokinentics, Faculty of Medicine and Biomedical Sciences, University of Yaound, Cameroon, Tel +237 670902446 Received: December 19, 2017 | Published: January 9, 2018 Citation: Fokunang CN, Fokunang ET, Frederick K, et al

The pentose phosphate pathway is the only source of NADPH in red blood cells, and the major function of NADPH in this cell type is to maintain the tripeptide glutathione (GSH) in its reduced state, which is needed to detoxify reactive oxygen species (Figure 3)