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Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease

In summary, this study analyzes the neuroprotective mechanism of DCA in ischemic stroke and the contradiction of the different research results, and discusses the causes and solutions of its adverse effects

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J Rehabil R D

In the oxidation mode, the one-electron reduction of quinones generates the highly reactive semiquinone radical leading to generation of superoxide anions (Figure 2)

In ALS, cytosolic TDP-43 translocated into mitochondria via TOM20, triggering ROS production and mitochondrial DNA (mtDNA) release through the mitochondrial permeability transition pore (mPTP)