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doi: 10.1016/s0891-5849(02)01197-8

doi: 10.1089/jmf.2017.0068 150

Touching vial tops with bare hands introduces bacteria

Pro-inflammatory cytokines, particularly IL-1, TNF-, and IL-6, are key mediators that stimulate chondrocytes to upregulate degradative enzymes such as matrix metalloproteinases (MMP-1, MMP-3, MMP-13) and aggrecanases (ADAMTS-4 and ADAMTS-5)