DBCO-Dap(m-PEG4)-Val-Cit-PAB deuterium-labeled-ketone Nature Chem 5

Nature Chem 5

S)-AHPC-CO-PEG2-OH Synonyms CAS Number n/a Related CAS Molecular Formula C27H38N4O6S Molecular Weight 546

Product Name Thalidomide-O-PEG3-C2-acid Synonyms Thalidomide-4'-O-PEG3-C2-acid CAS Number 2324154-35-8 Related CAS Molecular Formula C22H26N2O10 Molecular Weight 478

Product Name DOTA-PEG6-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C30H56N8O13 Molecular Weight 736

697 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCC#C)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Dap(m-PEG4)-Val-Cit-PAB deuterium-labeled-ketone Nature Chem 5SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,