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4.4.5 Modulation of the FSP1CoQNADH pathway to inhibit ferroptosis in PD FSP1, originally identified as apoptosis-inducing factor mitochondria-derived 2 (AIFM2), is an NAD(P)H-dependent ubiquinone reductase that functions independently of the canonical GSHGPX4 axis (279)

moreover, drug-metabolizing enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferase (GST) can participate in antioxidant defense as well (Bouov and Sklov 2012