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NRF2 is a tumour suppressor gene that also controls stem cell fate and the crosstalk between NRF2 and HSMGSH metabolism might have significant consequences beyond cancer

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10.3390/ph16070908 44 NeshanM.CampbellA.MalakoutiS

Cramping episodes lasting longer than 10 minutes, occurring multiple times weekly, or accompanied by color changes in toes warrant medical evaluation for circulation disorders

For managing nausea specifically, the following strategies may help: Eating cold or room-temperature foods , which tend to have less aroma and are often better tolerated than hot meals Ginger-based foods or drinks (for example, ginger tea or ginger biscuits) there is modest evidence supporting ginger's role in reducing nausea [24] [25] Resting upright for 3060 minutes after eating to support gastric transit Avoiding strong food smells during preparation if nausea is prominent Constipation is another common side effect associated with GLP-1based therapies

Giulivi, C., Traaseth, N