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Efficacy and safety of opicinumab in participants with relapsing multiple sclerosis: a randomized, placebo-controlled, phase 2 trial (AFFINITY part 1)

Instead of showing symmetric occupancy of the area between the N-terminal motifs of adjacent monomeric units within a tetramer, they show a preferential occupancy on one particular side (Fig

J., Takahashi, M

Nov 15 2012;84(10):1260-7

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In the MD stable conformation of hTYR, GSH_c forms hydrogen bonds with residues in the L2 and L4 regions, spanning these regions and ultimately chelating with both copper ions