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Recall that one of the surprising findings with DR (and reduced tryptophan) was the ability of animals to reproduce at ages when ad lib fed animals were long postreproductive

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Gene polymorphism has also been linked to ALI pathogenesis, such as insertion/deletion in the angiotensin-converting enzyme gene [101], and variant alleles of Pre-B-cell colony-enhancing factor (PBEF)[102], interleukin 18 (IL-18) [103], and mannose-binding lectin-2 (MBL-2) [104]

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