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IGF-1 LR3 functions through direct, sustained agonism of the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase, activating the same downstream intracellular signalling cascades as native IGF-1 but with substantially reduced IGFBP-mediated attenuation and a far longer biological activity window

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For example, MarR is glutathionylated under oxidative conditions, 89 suggesting that other thiol-containing proteins, potentially including antibiotic targets or regulators, may also be modified in vivo

2011;6:e27053