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Science 344 , 1237 (2014)

Without these data, even a positive skin outcome would be difficult to attribute to a specific mechanism, and a safe cumulative-dose ceiling could not be defined

O.EgorovE

This distinction underscores the importance of viewing GLP-1RAs as systemic immunometabolic modulators with secondary effects on thyroid autoimmunity, rather than as agents with direct thyroidal targets