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B-cell specific ablation of ChAT increases the mortality of mice subjected to partial hepatectomy compared to their wildtype counterpart, due to dysregulation of 7nAChR expressing Kupffer cells and CD8 + T cells, limiting their regenerative capacity and producing harmful IFN-, respectively (112)

Liu JM, Zhao HY, Ning G, Chen Y, Zhang LZ, Sun LH, Zhao YJ, Xu MY, Chen JL

[DOI] [PMC free article] [PubMed] [Google Scholar] 251.Tavassolifar M.J., Aghdaei H.A., Sadatpour O., Maleknia S., Fayazzadeh S., Mohebbi S.R., Montazer F., Rabbani A., Zali M.R., Izad M., et al

doi: 10.1126/science.1241165 184 HaghikiaAJrgSDuschaABergJManzelAWaschbischAet al

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Previous studies have identified drug-resistance mechanisms of tumor cells, including reducing drug absorption, increasing drug efflux via transporter proteins, detoxifying antitumor drugs via the glutathione system, and causing abnormalities in apoptotic pathways to reduce tumor cell apoptosis (9,10)