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In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

TBI pathology involves primary injury directly induced by biomechanical forces, succeeded by secondary injury mediated by excitotoxicity, calcium dyshomeostasis, oxidative stress, neuroinflammation, and mitochondrial dysfunction (Maas et al., 2017)

As the oxidative burden on the nervous system decreases, the autonomic nervous system can begin to shift back toward parasympathetic dominance (the "rest-and-digest" state)

2019;17:400 Zohny SM, Habib MZ, Mohamad MI, Elayat WM, Elhossiny RM, El-Salam MFA, et al

It is vital to treat the symptoms of anaphylaxis or Stevens-Johnson syndrome as medical emergencies when they occur

Evidence From Preclinical & Clinical Studies A) Skin permeation & bioavailability In-vitro penetration: A Franz-cell model showed human skin penetration of GHK-Cu in vitro, supporting the feasibility of topical delivery (PMC)