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During the healing stage of HSV infection on the tongue dorsum, lesions are often depressed granulating ulcers with sharply demarcated borders, a condition referred to as herpetic geographic glossitis. Oral recrudescent varicella-zoster virus usually presents as clustered ulcers affecting one side of the mouth but atypical findings may be noted in patients who are immunocompromised

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The UAB researchers compared lung tissue samples from nine never smokers, who had zero history of cigarette smoking, and lung tissue samples from 13 ever smokers with COPD who had a history of smoking that ranged from 15 to 25 pack years per person