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Functional Signaling Metabolites Produced by the Microbiome Metabolite production, including that of short-chain fatty acids, bile acids, and neurotransmitters, are another mechanism by which the gut-brain axis can modify substance use disorders (Cryan and Dinan 2012)

Please do not self-medicate with nicotine/tobacco products, he pleads

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Furthermore, in an animal study, nicotine was shown to promote tumor growth, mainly by activating the -adrenoceptors and the subsequent expression of cyclooxygenase-2, prostaglandin E2, and VEGF in tumor tissues (79)

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