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Inhibition or depletion of GPX4 leads to an accumulation of lipid peroxides and ultimately triggers ferroptotic cell death (Yang et al., 2014)

This IV therapy is primarily based on glutathione, which is a known antioxidant naturally produced by the human body

There are high amounts found in the lining of the respiratory and nasal cavities of the body

Flavonoids comprise a variety of biologically active compounds, among which there were some components of various medicinal preparations to treat a few human illnesses over thousands of years

Conclusion: NAFLDsym, a QSP model of NAFLD/NASH, was used to investigate the combination of mechanisms playing a role in AXA-1125, a NASH therapeutic candidate