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Smoke also contains nitrosamines and urethane, which cause leukemia in animals, and also contain styrene and agricultural chemicals that are a potential source of leukemia in humans [68]

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Mnard C, Hodes GE, Russo SJ

two were burned in the filming." Orson Welles, director (press statement, 1941): "The most basic of all ideas was that of a search for the true significance of the man's apparently meaningless dying words

Theres no exact timeframe, but patterns that continue for months or years especially with increased tolerance or cravings typically indicate chronic use

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