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Despite successful detorsion, 12%-68% of cases still suffer testicular atrophy and permanent dysfunction (92), which is due to excessive production of ROS, causing membrane lipid peroxidation, protein degeneration and DNA damage, cell dysfunction, and eventually apoptosis (93) during reperfusion

Initially, these chaperones together provide a proper folding of nascent proteins closer to 80S ribosomal subunit in eukaryotes (Han B

3.2 Regulation of TCM on ferroptosis through lipid metabolism pathway Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) play crucial roles in promoting lipid peroxidation during ferroptosis

In conclusion, biochemical, histopathological, and immunohistochemical results of our study led us to emphasize the reno-protective benefits of LS and GSH, either separately or in combination, when used either traditionally or in conjunction with NPs, can protect kidney structure and function from damage caused by GN

This impact can be attributed to the redox-buffering and antioxidant activities of rutin and aescin 58,59

Moreover, energy metabolism strongly influences the inflammatory response of microglia ( Inhibiting microglia ferroptosis to ameliorate CNS inflammation is a promising therapeutic tool for depression