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The cases were compared to 42 hepatosteatosis-free healthy controls

As TDP-43 SUMOylation plays roles in regulating TDP-43 clearance during recovery from stress, blocking TDP-43 SUMOylation in the TDP-43 K408R/K408R mouse line disrupts this proteostasis and leads to subsequent mislocalization consistent with loss of nuclear function

The next section discusses criteria regarding the design and development of drugs to treat AD

doi: 10.1186/s12916-018-1016-8 97 JinY.LiF.SonoustounB.KondruN

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The cells were then washed with PBS, fixed in 4% paraformaldehyde (100 L/well), and nuclei were stained with 40 M of 4, 6-diamidino-2-phenylindole (DAPI)