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However, free iron in mitochondria and the cytoplasm can generate highly oxidative HO, which damages polyunsaturated fatty acids (PUFAs) in the phospholipid bilayer, leading to mitochondrial outer membrane permeabilization (MOMP), ultimately abrogating DNA stability and inducing cell death

Munoz M, Villar I, Garcia-Erce JA

Generally, the tissue distribution and the persistence of expression of lipoplex and polyplex systems is mainly dependent, like with small molecular drugs following parenteral administration, also on the pharmacokinetics (clearance, distribution volume), the formulation (size, charge, PEGylation, etc.) and the dosage regimen (high volume bolus, sequential injection, constant infusion)

Heres a rundown 4 : Eyes: Prevents AMD and cataracts, scavenges free radicals, reduces malonaldehyde (MDA) levels, and protects against UV light

KEY TAKEAWAY The No

doi:10.1038/43686 51