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A Clinically Responsible Approach to BPC-157 The preclinical literature on BPC-157 presents a mechanistically coherent body of evidence, particularly in the areas of angiogenesis, gastrointestinal protection, and connective tissue repair

The continued successful development of GalNAc-siRNA therapeutics relies on the use of validated preclinical models for screening and optimization

Good intestinal barrier function requires tight junctions between intestinal epithelial cells [86]

doi: 10.4415/ANN_16_02_12 52 PascaleA.MarchesiN.GovoniS.CoppolaA.GazzarusoC

*Correspondence: Hamid Arazi [email protected] This article was submitted to Sport and Exercise Nutrition, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The accumulation of these peptides forms aggregates (fibrils) that may further assemble into plaques (135)