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World Development 2007

128 Likewise, in macrophages, lactylation of K33 on NEDD4, a crucial E3 ubiquitin ligase, reduces the ubiquitination of Caspase-11 by diminishing their binding affinity, leading to Caspase-11-dependent non-canonical pyroptosis

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While the identification of the pathogenic mechanisms that drive diabetes progression has continued to increase at an exponential rate, there are certain fundamental factors throughout a persons life that influence their risk of developing diabetic outcomes