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TLR-4 Agonist Induces IFN- Production Selectively in Proinflammatory Human M1 Macrophages through the PI3K-mTOR- and JNK-MAPK-Activated p70S6K Pathway [J

It recognizes pathogens and poisons through Toll-like receptors (TLRs) on its surface and initiates phagocytosis and immune responses

2.3 Neurooxidative stress and cognitive dysfunction in diabetes The brain is the most oxygen-consuming organ in the human body, with the normal human brain accounting for more than 20 to 30 percent of the bodys total oxygen consumption, but the brain is low in antioxidants, making it more susceptible to the effects of oxidative stress (39)