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For example, the CDC later revised its estimate of the annual number of Lyme disease cases in the United States from approximately 30,000 reported surveillance cases to an estimated more than 300,000 infections annually, acknowledging that surveillance figures substantially underestimated the true burden of disease

Klessig, [email protected] Specialty section: This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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