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Among users who post about side effects, the most-discussed run nausea, fatigue, GI-other, anxiety, diarrhea, constipation, menstrual changes, and reflux/burps, in that order

[133] showed that, compared to a healthy population, fecal samples from PD patients had a significant reduction in Prevotellaceae (77.6%) alongside an increase in Enterobacteriaceae

free-radical production, inflammation, gut-blood permeability increase

Circulation 2006

Despite limited investigation of sex and other biological variables potentially influencing ketamines opioid-dependent therapeutic efficacy, preliminary preclinical work suggests subanesthetic ketamine evokes opioid-mediated behavioral and neurophysiological effects in male but not female rats 46