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258 Furthermore, ruxolitinib, a pioneering JAK inhibitor and the first FDA-approved agent for intermediate- and high-risk myelofibrosis, represents a milestone in cancer therapy by modulating the tumor microenvironment through suppression of systemic inflammation in this rare and lethal myeloproliferative neoplasm

10.1038/s41467-021-23793-7 [DOI] [PMC free article] [PubMed] [Google Scholar] 51.Pouzin C, Gibiansky L, Fagniez N, Chadjaa M, Tod M, Nguyen L (2022) Integrated multiple analytes and semi-mechanistic population pharmacokinetic model of Tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drug conjugate

NEDD8 binding to the yeast proteasome allows substrate delivery and degradation if there is a flexible initiation region for engagement

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