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Complementing these pharmacological findings, genetic approaches using Hv1 knockout, knockdown, and overexpression models demonstrated that Hv1 loss attenuates NF-Bmediated cytokine production and PI3K/Akt/HIF-1dependent glycolytic reprogramming in microglia in a LPS-induced hippocampal neuroinflammation model ( Collectively, these findings emphasize Hv1 involvement in demyelinating diseases and neuroinflammation

Zhou Z, Sun X, Kang YJ (2001) Ethanol-induced apoptosis in mouse liver: fas-and cytochrome c-mediated caspase-3 activation pathway

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