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Yes long-term use is generally safe when taken as directed

For non-randomized studies, including cohort and casecontrol studies, the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool (Sterne et al., 2016) was employed to assess methodological quality across seven key domains: (1) bias due to confounding, (2) bias due to selection of participants, (3) bias in classification of interventions, (4) bias due to deviations from intended interventions, (5) bias due to missing data, (6) bias in measurement of outcomes, and (7) bias in selection of the reported result

The converse is also true

Turkish J Entomol 39(4)

Oualha, M

[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Russell RR, 3rd, Cline GW, Guthrie PH, Goodwin GW, Shulman GI, Taegtmeyer H