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APOE-4 exhibits strong sex-dependent effects, with womenparticularly in mid-to-late older adulthoodshowing greater vulnerability to ADrelated neurodegeneration than men, including increased tau accumulation, more pronounced hippocampal and temporal cortical atrophy, and greater cognitive and neuropsychiatric burden (118, 121, 122)

In: Liu Y, et al

It is administered via injection to ensure rapid absorption and effectiveness in addressing Vitamin B12 deficiency

Post-translational modification (PTM) of proteins involves the addition of moieties to target residues

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Moreover, CA, is transdiagnostically associated to psychiatry morbidity, and seems to play a role in the DNAm dysregulation of many of these pathways