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You start at a low dose and escalate gradually to minimize side effects, and you stay at your peak dose until you reach your target weight or plateau

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The interface with autophagy extends the role of endocytosis as a sorting mechanism for delivery of internalized cargoes to varied cellular destinations to include the routing of non-essential endocytosed materials to lysosomes for clearance

It is usually used when symptoms of parkinsonism cause a certain degree of disability and, usually, its use is avoided at the beginning of the disease, since it usually causes dyskinesia and worsen other symptoms such as postural hypotension and psychiatric symptoms

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The Cu2+ ion is coordinated by the histidine imidazole nitrogen and the N-terminal amino group of glycine, forming a specific metal-peptide complex