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Although GLS inhibition is effective in hematologic and some solid cancers, PDAC displays adaptive metabolic networks that sustain proliferation during GLS inhibition and rarely shows any beneficial therapeutic effects

It has been used to treat some nutrition based disease such as dementia, rheumatoid arthritis and exerts neuronal protection by promoting regeneration to injured nerves

Fernndez-Montes, A

To provide a comprehensive characterization of between-study variability and to illustrate the range of plausible effects for future research, we calculated 95% prediction intervals (PIs) alongside the 95% confidence intervals (CIs) for the pooled estimates, and statistical significance was defined as p = 0.05

Activation of AT 2 receptors expressed in macrophages is also implicated in neuropathic pain 11,12 , and the effectiveness of AT 2 receptor antagonists against neuropathic pain has been demonstrated in clinical and preclinical studies 13,14,15

T., Christie, K