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Senescent cells can arise throughout the lifespan and, if persistent, can have deleterious effects on tissue function due to the many proteins they secrete

Vanhee C, et al

Hyer, MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo

[4] The peptide is investigated almost exclusively for tissue repair endpoints: gastrointestinal ulcer healing, tendon and ligament repair, muscle injury, and various models of organ protection

It is not a clinical outcome, and the leap from modulates gene expression in vitro to produces a therapeutic effect in a person is exactly the leap that most preclinical findings fail to make

Since GHK-Cu operates through different mechanisms (gene expression modulation, collagen synthesis, stem cell activation), non-responders to minoxidil may achieve results through this alternative pathway