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References 1 ScherJUOgdieAMerolaJFRitchlinC

Under oxidative stress, NRF2 was released from KEAP1, translocated into and accumulated in the nucleus to induce expression of its target genes, and increased the expression of antioxidant enzymes like SODs and HOs families 60

Paeonol, the major bioactive compound in peony bark, is a natural free radical scavenger with antioxidant, anti-inflammatory, and cartilage-protective properties

Certificate of Analysis Tested by Freedom Diagnostics 03/23/2026 Tested by Janoshik 11/10/2025 Key Ingredients A four-amino acid peptide (AEDG) studied for its ability to activate telomerase in human somatic cells and regulate melatonin production via pineal gland modulation

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