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Is this arrest beneficial or detrimental to chemotherapy response

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once every 3 weeks for 3 months) solution is well tolerated in rats at doses up to 200 mg/kg with no life-threatening toxicity, and the STD 10 is greater than 200 mg/kg [2]

Emerging evidence indicates marked differences between primary and metastatic lesions in terms of metabolite composition, mitochondrial activity, ROS levels, and the architecture of the tumor microenvironment [17,18,19,20]

10 In instances where thiopurine therapy is not tolerated, is contraindicated or, increasingly, is not preferred because of its increased risk of infections and certain malignancies, the use of advanced therapies for ongoing maintenance therapy following steroid induction is indicated

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