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Molecular Medicine 30 (1), 7

Okabe S, Moriyama M, Arai Y, Gotoh A

In the healthy brain, most APP processing takes place through the non-amyloidogenic pathway, which avoids the production of the toxic amyloid- peptide (Sisodia et al, 1990

Frontiers in Pharmacology , 2022

What Happens Next A favorable vote starts a long process, not a quick switch

CDCl 3 ) 174.4 (C, CO 2 H), 156.1 (C, FmocCO), 143.7 (C, Fmoc), 141.3 (C, Fmoc), 127.8 (CH, Fmoc), 127.1 (CH, Fmoc), 125.2 (CH, Fmoc), 120.0 (CH, Fmoc), 72.4 (CH, C-4), 67.5 (CH 2 , FmocCH 2 ), 64.2 (CH 2 , C-9), 53.6 (CH, C-1), 47.1 (CH, FmocCH), 36.5 (CH 2 , C-3), 34.6 (CH 2 , C-2), 34.3 (2CH 2 , PamCH 2a alkyl), 33.0 (CH 2 , C-5), 31.9 (2CH 2 , PamCH 2 alkyl) 29.7-28.4 (21CH 2 , PamCH 2 alkyl, C-8), 25.5 (CH 2 , C-7), 25.0 (2CH 2 , PamCH 2 alkyl), 24.8 (CH 2 , C-6), 22.7 (2CH 2 , PamCH 2 alkyl), 14.1 (2CH 3 , PamCH 3 alkyl)