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Combustion only occurs when there are three main elements: fuel, heat, and oxygen

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however, BRFSS estimates are comparable with current smoking estimates obtained from other surveys with higher response rates.8 Finally, data were based on self-reports, and smoking status in BRFSS is not validated by biochemical markers

Effects of cigarette smoke on immune response: chronic exposure to cigarette smoke impairs antigen-mediated signaling in T cells and depletes IP3-sensitive Ca 2+ stores

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2 Centers for Disease Control and Prevention