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108,109 For example, in a single-site vehicle-controlled double-blinded study examining 79 female subjects aged 5380 years that applied the MEP treatment twice per day for 14 weeks displayed significant improvement in facial skin dryness, laxity, and dullness (Figure 6)

Nitrosative Stress: B12 as a Nitric Oxide (NO) Scavenger Excess nitric oxide (chemical formula: NO) also binds to vitamin B12, preventing nitrosative/oxidative free radical stress

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Ultrastructural analysis showed abundant electron-dense granular deposits and electron-dense lamellate lipid-like deposits that formed concentric bodies (zebra bodies) in the cytoplasm of podocytes and tubules

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Despite this, I think its actually still valuable to run some basic tests if you suspect B12