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The FDA has determined that these products, described as natural and additive-free on their labeling, need an FDA modified risk tobacco product order before they can be legally introduced as such into interstate commerce, the agency said in a statement

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It has been reported that cigarette smoke along with LPS leads to over-expression of proinflammatory cytokines such as interleukin (IL) 1, tumor necrosis factor- (TNF-), IL-6 and interferon- (INF-)

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