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Brain organoids enable the assessment of specific mtDNA and nDNA mutations during neurodevelopment in a human disease context

T., Vranje, D., Vukojevi, J., Tufan, M., Seiwerth, S., Sikiric, P

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In contrast to the effect vitamin C has in reprogramming and stem cell cultures, which is to reduce ROS, increase proliferation and protect cells from apoptosis, vitamin C treatment of cancer cells correlates with an increase in ROS-mediated oxidative stress and reduced viability (Noguera et al., 2017

Data were analyzed using reflexive thematic analysis informed by Braun and Clarkes six-phase framework: familiarization with the dataset, generating initial codes, constructing candidate themes, reviewing themes, defining and naming themes, and producing the report