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Proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), the master regulator of mitochondrial biogenesis, is progressively lost in tumor-infiltrating CD8+ T cells

Yanyan Zhou, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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A cascade hypothesis The prevailing pathogenic hypothesis for AD is the amyloid cascade hypothesis, which claims that amyloid precursor protein (APP) is cleaved to produce A, leading to the aggregation of oligomers [23, 24]

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ROS, as natural metabolic byproducts, have been shown to damage nucleic acids, proteins, and lipids through mechanisms such as DNA mutations, lipid peroxidation, and altered post-translational modifications, ultimately compromising cellular integrity