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B12 injections are clinically indicated for patients with confirmed deficiency or malabsorption conditions, including those with pernicious anaemia, gastrectomy, ileal resection, Crohn's disease, or neurological symptoms related to B12 deficiency

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These receptors are highly concentrated in adipose tissue (particularly visceral fat and brown fat) but have limited expression in most other tissues in adult humans

Vitamin B12 is a water-soluble vitamin that supports: Red blood cell production Nervous system function DNA synthesis Energy metabolism B12 injections deliver this essential nutrient directly into the bloodstream, bypassing absorption issues that come with oral supplements

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In the studied context, a review of six clinical trials found a safety profile comparable to placebo, without the IGF-1 effects of full growth hormone