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In vitro experiments further disclosed the inhibitory effect of sUA on the monocyte Toll-like receptor (TLR) signaling pathway, which in turn reduces the migration capability of classical monocytes ( Macrophages Macrophages in most tissues have diverse functions, including initiating immune and inflammatory responses toward pathogens, maintaining tissue homeostasis, and contributing to tissue repair and remodeling ( Figure 2 )

Cancer Cell 35 , 721737.e9 (2019)

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To assess whether the senescent phenotype induced by T-DXd was reversible or sustained, we performed washout experiments at different time points: in particular, cells treated with the ADC were allowed to recover in normal growth medium for either 3 or 7 days after the end of treatment

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