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Postmortem studies have revealed the aggregation of -synuclein in neurons around pigment-associated lipids under oxidative conditions, and this aggregation may participate in neuronal death in PD (Halliday et al., 2005)

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2.5.1.1 Small molecules analysis Compounds in the samples analyzed between 2020 and 2023 were identified using a high-performance liquid chromatograph (Ultimate 3,000 system from Dionex, Thermo Fisher Scientific, Waltham, MA, United States) coupled with a high-resolution micrOTOF-QII hybrid mass spectrometer (Bruker Daltonik, Bremen, Germany)

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254 Recently promising results were reported for the use of an anti-ferroptotic compound in phase I clinical trials in amyotrophic lateral sclerosis (ALS) patients and PD patients