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In BV2 microglial cell lines subjected to lipopolysaccharide (LPS)-induced neuroinflammation, both lactylation-mediated inhibition of p53 activity and direct knockdown of p53 protein can disrupt the control of the NF-B inflammatory signaling pathway, ultimately leading to abnormal expression of pro-inflammatory factors and M1 polarization of microglia [132]

After plasma membrane sheets were obtained and verified by microscopic observation, the ice-cold K-Glu buffer was replaced with room-temperature K-Glu buffer, and they were incubated with 2 M recombinant -SNAP WT or M105I for 5 min (PBS alone was used as negative control)

Several hundred hemoglobinopathies caused by various mutations in globin genes are known, but only those associated with sickle cell disease are prevalent enough in the United States to merit discussion

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About 63% and 28% of the papers published in the last 20 years, with this alga, were in the categories of Web of Science Environmental Sciences and Toxicology, respectively, while only ~ 3% were published in the category Biochemistry and Molecular Biology

For practical research, it is better to measure CBS together with related pathway markers