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2002;282(5):F844-F852 34

K.MarrotL.et al (2010)

Furthermore, bridging the translational divide requires embedding mechanistic investigations (eg, biomarker analyses, advanced imaging to assess vascular remodeling) within clinical trials to validate whether mechanisms identified preclinically hold true in humans and provide a biological rationale for observed clinical effects

What the literature offers instead is a handful of fixed-duration administration schedules: 7 successive nights , placebo-controlled and double-blind, in 14 middle-aged chronic insomniacs