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Results: We discovered that the CC-oscillator temporally gates TGF- signaling and this regulation is broken in fibrosis

Ann N Y Acad Sci 2004;1033:42-51

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Nutrients 15 (14), 3204

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By contrast, the activation of SIRT1 enhances hepatic lipid catabolism and mitochondrial efficiency, serving as a critical counterbalance in the maintenance of metabolic adaptation during NAFLD progression (63)