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Importantly, this immunosuppression is rapid and reversible, and buffering extracellular acidity can restore CTL function even in the presence of high lactate levels [211]

10.4088/JCP.10r06710 53

Critically, SCFAs are master epigenetic regulators, acting as inhibitors of the enzyme histone deacetylase (HDAC), which is involved in the histone modification [194, 195]