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In approximately half of the cases, idebenone, a synthetic variant of CoQ10, has demonstrated effectiveness

Chem 279 , 2440324413 (2004)

In addition, recent work suggests that a number of stress paradigms applied to mice early in life leads to reduced concentration of metabolites produced and stored in neurons, namely glutamate, GABA and N -acetylaspartate, almost exclusively in the prefrontal cortex ([77] and references therein)

An effect of one electron oxidation by oxidants may result in the modification of protein-SH groups and consequently the formation of thiyl radicals (Protein-S ) and protein sulfenic acid (Protein-SOH) (Valko et al